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In the STEP 1 trial, semaglutide led to an average 14.9% reduction in body weight over 68 weeks , far outperforming placebo (NEJM study on semaglutide for weight loss)

Nitrous oxide, a commonly used anesthetic, oxidizes and inactivates vitamin B 12 , thus inhibiting both of the vitamin B 12 -dependent enzymes, and can produce many of the clinical features of vitamin B 12 deficiency, such as megaloblastic anemia and neuropathy

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This decline is believed to contribute to many age-related health issues, including metabolic dysfunction, neurodegenerative diseases, and a general reduction in cellular resilience

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